When clinically warranted, the topical use of testosterone replacement can be an effective treatment in males with hypogonadism. Various commercially available products exist, but occasionally the need for specialty compounding arises. This session seeks to evaluate the prescribing of testosterone replacement therapy and explore the appropriateness of specialty compounding. Challenges of compounding a topical testosterone replacement therapy and patient counseling points are identified and extrapolated for ‘best practice’ recommendations. This program has been ACPE accredited as a ‘compounding’ program.